Issue 1: Vol: 1 (April 2008)
Tiny Assembly Lines
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Researchers Drafting Plans for Tiny Assembly Lines

A University of Texas at Dallas team will play a key role in a new $15 million research project designed to enable manufacturing at an almost unimaginably small scale: one atom at a time.

"This breakthrough technology will make it possible to manufacture devices with atomic precision by exploiting our established ability to remove individual hydrogen atoms from a silicon surface using a scanning tunneling microscope," said Robert Wallace, a professor of materials science and engineering in the Erik Jonsson School of Engineering and Computer Science at UT Dallas and a co-principal investigator in the project.

Known as atomically precise manufacturing, the technique is expected to enable a wide variety of devices and products, including:

  • Ultra-low-power semiconductors for cellphones and other wireless communications.
  • Sensors with ultra-high sensitivity.
  • Data encryption orders of magnitude more secure than existing technology.
  • Optical elements that enable unprecedented performance in computing and communications.
  • Customized surfaces that would have an array of applications in the biomedical and pharmaceutical industries.
  • Nanoscale genomics arrays that would enable a person's complete genetic sequence to be read in less than two hours.

Futuristic technologies such as atomically precise manufacturing are a good example of the initiatives that are part of the University's Strategic Plan. Plans are for more investments in "tomorrow's inventions," especially in the natural sciences, medical sciences and engineering, all areas of great opportunity and impact. The UT Dallas team will focus its research on perfecting the ability to precisely control the reactions that take place on a silicon surface as the atom-by-atom assembly of a device takes place, said Wallace.

This is still not quite equivalent to molecular manufacturing, but it does represent a major step along the way. And make no mistake, that is the eventual goal of this team. Perhaps this sort of significant public investment in technologies leading directly toward molecular manufacturing is what causes analysts like this one to say:

Broadly speaking, nanotechnology deals with matter at the atomic and molecular scales. “Atomically precise manufacturing” (APM) is the real business of making things using nanotechnology. There is no more exciting area for investors to be in right now. . .

APM will not only create new opportunities, it will destroy many existing industries. Just as light bulbs and AC electrical power created huge opportunities, they razed whole sectors. Lucrative businesses crumbled, taking their investors’ fortunes with them. My goal is to make sure that you don’t wake up one morning to find that your portfolio consists of buggy whips and chemical-based photographic film.
Source: http://crnano.typepad.com/crnblog/2008/03/tiny-assembly-l.html


Troika To Manage $6 Billion For Russia State Nanotechnology Co.

Moscow-based Troika Dialogue Asset Management said Tuesday it has been hired to manage $6 billion of funds held by Russia's state nanotechnology investment company.

"The role of Troika Dialogue will be to deploy the money before it is invested in nanotechnology," the asset manager's President Pavel Teplukhin told Dow Jones Newswires at a conference in Singapore.

Russian Corporation of Nanotechnologies will entrust Troika Dialogue with the funds later this month, and the asset manager will invest mainly in the Russian bond market.

The new mandate will more than double the asset manager's current portfolio, which now totals about $5 billion.

Troika will be paid a fixed annual management fee and there will be no performance-based compensation.

Troika Dialogue Asset Management is a unit of privately-held investment bank Troika Dialogue Group.

Source: http://www.nanowerk.com/news/newsid=5147.php


The coming technological revolution

It seems like magic. A small appliance, about the size of a washing machine, that is able to manufacture almost anything. It is called a nanofactory. Fed with simple chemical stocks, this amazing machine breaks down molecules, and then reassembles them into any product you ask for. Packed with nanotechnology and robotics, weighing 200 pounds and standing half as tall as a person, it can produce two tons per day of products. Control is simple: a touch screen selects the type and number of products to produce. It costs very little to operate, just the price of materials fed into it. In one hour, $20 worth of chemicals can be converted into 100 pairs of shoes, or 50 shovels, or 200 cell phones, or even a duplicate nanofactory!

Impossible? Today, maybe, but not tomorrow. The technology to create such a machine is speedily being developed. A nanofactory will be the end result of a convergence between nanotechnology (molecular scale engineering), rapid prototyping, and automated assembly. These are all present-day technologies. None of them has yet reached its full potential, but each of them is advancing rapidly, driven by powerful economic, social, and military forces. The integration of the three technologies will be far more powerful than the sum of the parts.

Some experts claim that a crash program started today could complete the first working nanofactory within a decade at a cost of between five and ten billion dollars. And once the first one is built, it can start making copies of itself. Five to ten billion dollars is a lot of money, of course, and many people will question if it could not be better spent on something else. But imagine the economic, environmental and humanitarian benefits, when nearly any product can be manufactured on the spot for about $1 per pound. No more shipping costs or time spent waiting. No more wasted resources or hazardous byproducts. No more starvation, homelessness, or poverty.

Already scientists have made chemical reactions happen by directly manipulating the individual atoms. They can draw lines of chemicals only ten atoms wide. They can send electricity down molecular wires. They can attach propellers to molecular motors and analyze their performance. They can make functioning tweezers from DNA molecules. Within a few years, we will have the ability to build three-dimensional, active, molecular constructions. It's a small and predictable step to building robots and chemical plants at the nanometer scale.

It sounds too good to be true: a non-polluting, personal-size machine that within a few hours and for a few dollars can manufacture almost anything—clothing, books, tools, communication devices—but there is a catch. It can also manufacture weapons, poisons, tiny surveillance cameras, and other illicit products. How will this be controlled?
Imagine the possibilities! And the problems...

What we're doing about it

The mission of the Center for Responsible Nanotechnology (a non-profit program of World Care) is to raise awareness of the issues presented by molecular nanotechnology: the benefits and dangers, and the possibilities for responsible use.

Designing and developing molecular nanotechnology (MNT) is a major challenge in itself. It will not be easy, and it will not happen overnight. But it will happen, and it should happen. A greater challenge—and one that has not been addressed—is creating the infrastructure to administer the most powerful technology imaginable in a way that allows its safe and effective use, but that protects investors, users, and innocent bystanders.

"Nanotechnology will give rise to a host of novel social, ethical, philosophical and legal issues. It will be important to have a group in place to predict and work to alleviate anticipated problems."
— US Rep. Mike Honda (D-Cal.)

The technology is already on its way. But who will control it? If MNT is not administered properly, there is great risk of it being used badly—either by the entity that first develops it, or by groups that later gain access to it. Development or control of the technology by a special interest group would probably lead to military or economic oppression. Two competing programs could lead to an unstable arms race. Uncontrolled release would make the full power of the technology available to terrorists, criminals, dictators, and irresponsible users. The safest course appears to be a single, rapid, worldwide development program by an organization that recognizes the necessity of wise administration.

Christine Peterson of the Foresight Nanotech Institute made this point in her April 2003 testimony to the US House Committee on Science:

"In developing a powerful technology, delay may seem to add safety, but the opposite could be the case for molecular manufacturing. A targeted R&D project today aimed at this goal would need to be large and, therefore, visible and relatively easy to monitor. As time passes, the nanoscale infrastructure improves worldwide, enabling faster development everywhere, including places that are hard to monitor. The safest course may be to create a fast-moving, well-funded, highly-focused project located where it can be closely watched by all interested parties. Estimates are that such a project could reach its goal in 10-15 years."

CRN is dedicated to studying the problem of how to make MNT as safe as possible. We will find technological solutions and plan systems of administration. We will work to educate people at all levels about the dangers of nanotechnology, and the possible solutions to those dangers.

Beyond addressing measures of safety and environmental protection, we believe that responsible use of MNT should include consideration for ways to reduce the gap between the haves and the have-nots. This new technology can make a tremendous impact for good; unwise regulation might impede such hopes. As suggested in the Foresight Guidelines: "Experimenters and industry should have the maximum safe opportunities to develop and commercialize the molecular manufacturing industry. In addition, MNT should be developed in ways that make it possible to distribute the benefits of the technology to the four-fifths of humanity currently desperate to achieve material wealth at any environmental or security cost."

Effective administration will not be easy, and it is unlikely that a wise course of action can evolve without guidance. There are too many risks to avoid, too many benefits to preserve, and too many special interests to satisfy. A technology this powerful has implications in the areas of national security, commercial rights, human rights, global environment, and even cultural stability. Any single organization with a narrow focus will create too many regulations while trying to control things that it does not know how to control; too many regulations will create an unregulated black market, which creates unacceptable risks. We believe that MNT must be regulated at a global level, but the regulatory system must be designed with extreme care to be acceptable to the world's population—and to avoid the internal corruption that naturally accompanies so much power. The design of such a system is one of our main concerns.

Simple, non-factory forms of nanotechnology already are being developed, and already are raising safety questions. Although these simple forms are less dangerous—and less useful—than the advanced nanotechnology that is our main concern, we will be addressing today's issues of safety as well as tomorrow's.

The purpose of CRN is to investigate the wise use of molecular nanotechnology, and to educate those who will influence its use, or be affected by it. Through this we hope to see our vision made real: a world in which MNT is widely used for productive and beneficial purposes, and where malicious uses are limited by effective administration of the technology.

Source: http://www.crnano.org/magic.htm


Nextreme Awarded Seminal Patent in Nanotechnology to Boost Efficiency of Thermoelectrics

Nextreme Awarded US Patent for "Phonon-Blocking, Electron-Transmitting Low-Dimensional Structures" - a Technology That Enhances Cooling and Energy Conversion Efficiency

Nextreme Thermal Solutions(TM), the leader in microscale thermal and power management products for the electronics industry, announces that it has been awarded US Patent 7,342,169 for "Phonon-Blocking, Electron-Transmitting Low-Dimensional Structures" technology that has the potential to significantly impact energy conservation and thermal management - two major drivers in the world economy today. Nextreme's newest patent represents the culmination of pioneering work carried out by RTI International more than seven years ago in the area of nano-structured thermoelectric materials. Nextreme acquired all of RTI's intellectual property in thermoelectric materials and devices in 2004.

Thermoelectrics are used to convert waste heat into electrical power, and also for cooling electronics. Numerous researchers in North America have reported significantly enhanced efficiencies in thermoelectrics using nano-structured materials. This includes pioneering work on superlattices at RTI International and MIT that started in the 1990's and more recently at MIT and Boston College using nano-particles.

The nano-approach uses a commonly available thermoelectric material called Bismuth Telluride, constructed on a nanoscale to create an assembly that researchers believe blocks the transmission of phonons, which carry heat, and enhances the transmission of electrons, which carry electrical energy. The result is a radical boost in material efficiency with reports of 40% to 140% improvement.

"This patent award is the culmination of years of research from a pioneer in the field of thermoelectrics," said Dr. Seri Lee, Chief Technology Officer at Nextreme. "Nano-structured materials hold great promise for significantly enhanced cooling and energy conversion performance."Nextreme has already revolutionized the use of thin-film thermoelectrics in the electronics industry by integrating thermoelectric materials into commonly used electrical interconnects called copper pillar bumps to create a thermal bump. This approach has provided a scalable and inexpensive pathway for integrating thermal management functionality directly into electronic packaging and has enabled Nextreme's OptoCooler(TM) module, the world's smallest thermoelectric cooler and the industry's first device to offer a heat pumping density in excess of 70 W/cm(2).

Source: http://www.centredaily.com/business/technology/story/495232.html


Nanomaterial turns radiation directly into electricity

Materials that directly convert radiation into electricity could produce a new era of spacecraft and even Earth-based vehicles powered by high-powered nuclear batteries, say US researchers. Electricity is usually made using nuclear power by heating steam to rotate turbines that generate electricity.

But beginning in the 1960s, the US and Soviet Union used thermoelectric materials that convert heat into electricity to power spacecraft using nuclear fission or decaying radioactive material. The Pioneer missions were among those using the latter, "nuclear battery" approach.

Dispensing with the steam and turbines makes those systems smaller and less complicated. But thermoelectric materials have very low efficiency. Now US researchers say they have developed highly efficient materials that can convert the radiation, not heat, from nuclear materials and reactions into electricity.

Power boost

Liviu Popa-Simil, former Los Alamos National Laboratory nuclear engineer and founder of private research and development company LAVM and Claudiu Muntele, of Alabama A&M University, US, say transforming the energy of radioactive particles into electricity is more effective.

The materials they are testing would extract up to 20 times more power from radioactive decay than thermoelectric materials, they calculate.

Tests of layered tiles of carbon nanotubes packed with gold and surrounded by lithium hydride are under way. Radioactive particles that slam into the gold push out a shower of high-energy electrons. They pass through carbon nanotubes and pass into the lithium hydride from where they move into electrodes, allowing current to flow.

"You load the material with nuclear energy and unload an electric current," says Popa-Simil.

Space probes

The tiles would be best used to create electricity using a radioactive material, says Popa-Simil, because they could be embedded directly where radiation is greatest. But they could also harvest power directly from a fission reactor's radiation.

Devices based on the material could be small enough to power anything from interplanetary probes to aircraft and land vehicles, he adds.

"I believe this work is innovative and could have a significant impact on the future of nuclear power," says David Poston, of the US Department of Energy's Los Alamos National Laboratory. However perfecting new nuclear technologies requires years of development, he adds.

Popa-Simil agrees, saying it will be at least a decade before final designs of the radiation-to-electricity concept are built.

Changing the way we go about

Think about a world which can never be seen but really exists. Yes, this is the nanotechnology world which is not visible to the naked eye even with a light microscope.

It is denoted as nano because a nanometer is one-billionth of a meter, smaller than the wavelength of visible light and has a width hundred-thousandth times less than a human hair. In general, nanotechnology makes sense when something measures within the range between 1 and 100nm.

It was 1986 when Eric Drexler introduced the term nanotechnology and from then on the nano world went through many revolutionary changes. Recently more than 13,000 patents have been registered in the US. Nanotechnology has broad spectrum approach that successfully attracts biologists, chemists, physicists and engineers.

Until recently, researchers discovered two nano-sized structures namely nanowires and carbon nanotubes. Nanowires has very small diameter -- near about 1 nanometer. Researchers have developed it to construct tiny transistors for computer chips and other digital accessories. But the advent of carbon nanotube blurred the prospects of nanowires.

Basically carbon nanotube is a nano-size cylinder of carbon atoms. Imagine a sheet made of carbon atoms. If you roll the sheet and insert it into a tube then it becomes a carbon nanotube. Carbon nanotube properties depend on how you roll the sheet. Furthermore, although all carbon nanotubes are made of carbon, they can be very different from each other based on how the atoms are organised.

Due to the proper combination of atom, it is possible to develop a carbon nanotube which is hundreds of times stronger than steel, but six times lighter. Modern day engineers seriously consider carbon nanotubes as a manufacturing element to produce cars and aircrafts. A relatively weightless vehicle ensures easy to handle opportunity and reduces fuel cost.

With the proper combination of atoms it is possible to develop high quality semiconductor device. Scientists are still working on finding ways to make carbon nanotubes a realistic option for transistors in microprocessors and other electronics. Nowadays nanotechnology is implemented in several areas which is very astonishing. Many sunscreen-manufacturing companies today use nanoparticles of zinc oxide or titanium oxide to produce sunscreens. Older sunscreen ingredients are larger particles that are responsible for their whitish colour. Smaller particles are less visible, meaning that when you rub the sunscreen onto your skin, it doesn't give you a whitish tinge.

Researchers are now thinking about the prospects of nanotechnology in apparel industry. Integrating nanoparticles of zinc oxide, manufacturers can create clothes that act as protective shield to ultraviolet (UV) radiation. Some clothes have nanoparticles in the form of little hairs or whiskers that help repel water and other materials, making the clothing stain-resistant.

Nanotechnology has also its presence in solar power technology. Researchers are currently exploring the prospects of nanotechnology-based solar cell against traditional silicon-based solar cell. This new category of solar cells derived from nanocrystals will be capable of converting sunlight into electricity at a fraction of the cost of silicon solar cells. Silicon-based solar cells are made from a refined, highly purified silicon crystal, similar to those used in the manufacturing of integrated circuits and computer chips. The high costs of these silicon solar cells and their complex production process have generated interest in developing alternative photovoltaic technologies.

Besides high-end solutions nanotechnology can be utilised to develop stylish gadgets. A company called Pilkington offers a product they call Activ Glass, which uses nanoparticles to make the glass photocatalytic and hydrophilic. The photocatalytic effect means that when UV radiation from light hits the glass, nanoparticles become energized and begin to break down and loosen organic molecules on the glass. Hydrophilic means that when water makes contact with the glass, it spreads across the glass evenly, which helps wash the glass clean.

In medical science nanotechnology has a great significance. Nanotechnology has been used to create new and improved imaging techniques to find small tumours. Researchers have shown that incredibly small iron oxide particles (nanoparticulates) can be used with magnetic resonance imaging (MRI) to accurately detect cancers that have spread to lymph nodes, without requiring surgery.

In the near future, nanoscale devices may be available to detect the earliest stages of cancer while simultaneously delivering anticancer agents to the tumour. Early research has shown that nanoparticulate sensors can detect the cell death that occurs when a cancer cell succumbs to the effects of an anticancer drug.

It is worth mentioning that nanotechnology can effectively address the biological complexities. Nanrobots will mix with fluids programmed to attack and reconstruct the molecular structure of cancer cell and viruses. There's even speculation that nanorobots could slow or reverse the aging process, and life expectancy could increase significantly. Environmental concern is a great issue in recent times. Nanotechnology can bring breakthroughs to eliminate environmental catastrophes. For instance, scientists could program airborne nanorobots to rebuild the thinning ozone layer. Nanorobots could remove contaminants from water sources and clean up oil spills. Manufacturing materials using the bottom-up method of nanotechnology also creates less pollution than conventional manufacturing processes.

Although nano world promises substantial changes in the traditional world, suspicion remains about its side effects because elements at the nanoscale behave differently than they do in their usual form.

Some doctors worry that the nanoparticles are so small that they could easily cross the blood-brain barrier, a membrane that protects the brain from harmful chemicals in the bloodstream.

Nanotechnology may create some social obligations. For instance, this technology could be used to create more powerful weapons, both lethal and non-lethal. It may create imbalance in power which may result in unrest in the society. To deal with this phenomenon, some organisations have urged scientists and politicians to examine carefully all the possibilities of nanotechnology before designing increasingly powerful weapons.In essence, there is no doubt that nanotechnology has the power to empower the modern civilization. But implementers should first thrash out the ethical aspects of this new age technology.

Source: http://www.thedailystar.net/story.php?nid=26433



‘Happy tree’ yields a cancer-fighting drug

Vancouver Sun - B.C. cancer patients who don’t get better on standard treatment will be offered a locally developed experimental drug using a nanotechnology smart bomb type of treatment derived from the bark of the “happy tree,” indigenous to China.

Scientists at the B.C. Cancer Agency (Vancouver, Canada) have developed an anti-cancer weapon that is not unlike a cruise missile, which is meant to hit targets with precision. It’s been tested in mice and they say it’s now ready for testing in humans.

They are calling their drug Irinophore C; its compounds are originally derived from a somewhat stubby tree called Camptotheca (or happy tree), which was found 40 years ago to have anti-cancer properties that were eventually extracted and synthesized.

While at least one drug company markets a chemotherapy drug called Camptosar, based on the same tree compounds, B.C. Cancer Agency scientists maintain they have discovered a unique way to get a modified version into patients’ bodies using a drug delivery system that doesn’t release its load until it gets to the desired site of action. As the scientists discuss in a research journal, their own patented formula fits with the goal of an “ideal drug delivery system [which retains] its therapeutic payload until it reaches the target site whereupon the drug [is] released.” Dawn Waterhouse, director of non-clinical studies and manager of production and manufacturing with the cancer agency’s investigational drug program, said in an interview that in mice studies, the Irinophore C drug system was “remarkably better in therapeutic effect and less toxic” when compared to Camptosar. Animals were inoculated with human tumour cells from various types of cancer and then they got Camptosar or Irinophore C for treatment of the tumours they developed.

The cancer agency-developed drug accumulated in the tumours with far greater efficiency and that convinced the scientists that a phase-one trial in humans is now possible. A phase-one trial is meant to evaluate the safety of the drug, not the effectiveness.

Such a trial is not expected to start immediately since researchers need to get more grant funding before proceeding. Work so far on the “proof of principle” concept has been funded with a $250,000 grant from the Canadian Institutes for Health Research but that federal agency insists that matching funds be obtained from other partners. Scientists are now trying to secure at least another $1.1 million to start the trial in patients with various types of advanced cancers.

What’s unusual about the drug is that it is encapsulated in a fatty coating membrane called liposomes. The nanoscale technology aspect of the system relates to the fact that the fat molecules are so microscopically tiny (one-fifth the size of a red blood cell), which allows the drug to be infused into patients’ veins and then travel to cancer cells where it kills them and also disrupts the vascular system that feeds the growth of tumours. “In our phase-one trial, we will assess the safety of the drug in 18 patients with advanced solid tumours. “Patients will be those who have failed standard therapy and their cancer has progressed. These are patients for whom we have nothing more to offer except for investigational drugs,” Waterhouse said.

Nanotechnology; a Double Edged Sword

Nanotechnology is probably the most exciting technological development that the world has seen for generations. Commentators are keen to hail the new technology as a revolutionary step that will enter nearly every industry and practically all walks of life. Arguments are abounding that nanotechnology will revolutionise not just IT, but medicine, agriculture and manufacturing as well. New materials will be created to cater for the ever increasing demands of various industries. But while these benefits are touted by commentators, the potential downsides have been practically ignored. Surely the revolutionary technologies will have detrimental effects on life that will be near impossible to predict.

The first major concern can be seen as the lack of governmental controls and investigation into these new industries. Despite claims that they have the development under control, accounting for health and safety ramifications is essential. The applications for nanotechnology are so wide ranging that their effects are hard to predict. For instance the use of nanos in spy agencies will render human rights laws useless in the face of technologies too advanced to be detected.

Governments are however waking up to the risks of nanoparticles, with expert bodies advising that nanotechnologies should be put under the same rigorous tests that new chemicals undergo to enforce safety of use and storage. The testing phase is fundamentally important as scientists have little idea how some nanoparticles will affect the body in large numbers.

While the socioeconomic effects of the new technologies have been studied extensively, the health and safety impacts are not understood enough. Without a universal procedure for the development, use and storage of nanotechnologies, health and safety standards cannot be defined. This may be a problem at the moment but doubtlessly a resolution will eventually be forthcoming.

With so many revolutionary uses for nanotechnologies, it is undeniable that their development will be pursued wholesale and with gusto. They are hailed as the future and scientists are very excited about which applications will seriously affect our lives. Despite the apparent risks to health and safety, most will have a Machiavellian attitude to the pursuit of what could be a technological revolution.
Source: http://blog.highposition.net/article/nanotechnology-a-double-edged-sword/45683

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